Yep, its impossible to make Anna be quiet. You can turn off her GPS route directions, yes. But Anna appears to be programmed to regularly answer ‘I need fans!’ every ten minutes or so, chucking a suggestion at you whether you want it or not. Worse yet, even when there are no fans to earn, she still pretends you’re saying ‘I need fans!’ every ten minutes, to which she will answer, out of nowhere, that you’ve completed everything and there’s no more fans to earn.
“There is a bucket list event you haven’t completed. Would you like me to set a route?” no, no I wouldn’t. I’ve used ANNA 84 times apparently and 83 of those times the answer was no, the 1 yes was me hitting the wrong button.
ANNA only asks you every 5 seconds because developers/publishers think their customers are stupid and can’t think for themselves. Its why every game has X-ray vision these days or why your character says the most obvious situational statements.